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At the same time, carbon dioxide leaves the blood and enters the alveolar space where it can be pushed out during exhalation.The balance of the amount of blood flowing through the capillaries and the amount of air inside the alveoli must be carefully regulated throughout the lungs (called ventilation-perfusion matching). If there is not enough blood flow the under-perfused alveoli are wasted space (called dead space). If there is insufficient air for the amount of blood that perfuses an area of the lung, the blood will not be sufficiently oxygenated and hence the overall blood exiting the lungs may have too low an oxygen supply to fulfill the cell needs.Oxygen does not dissolve well in water (the liquid part of blood is mostly water), so the amount of oxygen blood can carry in solution is very limited. Red blood cells (RBCs) bind oxygen, allowing the blood to carry much more oxygen in order to supply the body needs. In fact, about 98 percent of the oxygen in blood is bound to RBCs.Many diseases can cause an imbalance in the ventilation-perfusion match of the lungs. Diseases that prevent normal air filling of the alveoli include those that cause excessive air flow resistance in the airways (such as asthma or emphysema), those that log up?the alveoli (such as congestive heart failure which can cause fluid to build up in the alveoli or pneumonia which can cause infection and inflammation within the alveoli), as well as many other conditions. Diseases that prevent sufficient blood supply to the alveoli include blockage of the pulmonary arteries (such as pulmonary emboli) and many other conditions. Some diseases compromise the lungs in other ways, such as a collapsed lung.Page 2 of 2 - Many conditions can also affect the ability of oxygen to bind to RBCs. 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