While saving images and important settings/details into the database and accessing it from the database we can define its default path in the Web.config.

<?xml version="1.0"?>
<configuration>

  <connectionStrings>
    <add connectionString="Data Source=myserver;Initial Catalog=demo;User ID=sa;Password=demo@123" name="DBConnectionString" providerName="System.Data.SqlClient" />
  </connectionStrings>
  
  <appSettings>
    <add key="aspnet:UseTaskFriendlySynchronizationContext" value="true" />
    <add key="DefaultProfileImage" value="DefaultProfile.png"/>
    <add key="BaseAddress" value="http://192.178.12.1/"   />
    <add key="ProfileImageBaseAddress" value="ProfileImages/"   />
    <add key="PasswordResetSubject" value="Password Reset - Nudge Energy"/>
    <add key="ForgotPasswordLength" value="5"/>
    
    <!-- Mail Setting (Testing) -->
    <add key="SenderEmailID" value="demomail@gmail.com" />
    <add key="SenderPassword" value="demo@02" />
    <add key="EnableSSl" value="true" />
    <add key="SenderAddress" value="demo@solutions.com" />
    <add key="DisplayName" value="DeoModule" />
    <add key="Host" value="smtp.gmail.com" />
    <add key="Port" value="587" />
  </appSettings>
  <system.web>
    <compilation debug="true" strict="false" explicit="true" targetFramework="4.5" />
    <httpRuntime targetFramework="4.5"/>
  </system.web>
  <system.serviceModel>
    <bindings>
      <basicHttpBinding>
        <binding  maxReceivedMessageSize="2147483647">
          <readerQuotas
            maxDepth="64"
            maxStringContentLength="2147483647"
            maxArrayLength="2147483647"
            maxBytesPerRead="4096"
            maxNameTableCharCount="16384"/>
        </binding>
      </basicHttpBinding>
    </bindings>
    <serviceHostingEnvironment aspNetCompatibilityEnabled="true" />
    <services>
      <service behaviorConfiguration="NudgeDemoAPI.NudgeServiceBehavior"
        name="NudgeDemoAPI.NudgeService">
        <endpoint behaviorConfiguration="webBehavior" binding="webHttpBinding"
          contract="NudgeDemoAPI.INudgeService" />
        <endpoint address="mex" binding="mexHttpBinding" contract="IMetadataExchange" />
      </service>
    </services>

    <behaviors>
      <serviceBehaviors>
        <behavior name="NudgeDemoAPI.NudgeServiceBehavior">
          <!-- To avoid disclosing metadata information, 
          set the value below to false before deployment -->
          <serviceMetadata httpGetEnabled="True"/>
          <!-- To receive exception details in faults for debugging purposes, 
          set the value below to true.  Set to false before deployment 
          to avoid disclosing exception information -->
          <serviceDebug includeExceptionDetailInFaults="True" />
        </behavior>
      </serviceBehaviors>
      <endpointBehaviors>
        <behavior name="webBehavior">
          <webHttp defaultOutgoingResponseFormat="Json" />
        </behavior>
      </endpointBehaviors>
    </behaviors>
  </system.serviceModel>
  <system.webServer>
    <modules runAllManagedModulesForAllRequests="true"/>
    <!--
        To browse web app root directory during debugging, set the value below to true.
        Set to false before deployment to avoid disclosing web app folder information.
      -->
    <directoryBrowse enabled="true"/>
  </system.webServer>

</configuration>

And we can access it while coding like this

 public EmployeeResponse RegisterEmployee(EmployeeRequest empobj)
        {
            try
            {
                int result = 0;
                string accessToken = Guid.NewGuid().ToString();
                empResponse = new EmployeeResponse();
                using (SqlConnection sqlConnection = new SqlConnection(ConnectionString))
                {
                    if (sqlConnection.State == ConnectionState.Closed)
                    {
                        sqlConnection.Open();
                    }
                    SqlCommand cmd = new SqlCommand("uspRegisterUser", sqlConnection);
                    cmd.CommandType = CommandType.StoredProcedure;
                    cmd.Parameters.Add("@FirstName", SqlDbType.VarChar, 50).Value = empobj.FirstName;
                    cmd.Parameters.Add("@LastName", SqlDbType.VarChar, 50).Value = empobj.LastName;
                    cmd.Parameters.Add("@ProfileImage", SqlDbType.VarChar, 500).Value = ConfigurationManager.AppSettings["ProfileImageBaseAddress"].ToString();
                    cmd.Parameters.Add("@JobRoleID", SqlDbType.BigInt).Value = empobj.JobRoleID;
                    cmd.Parameters.Add("@Email", SqlDbType.VarChar, 200).Value = empobj.Email;
                    cmd.Parameters.Add("@CompanyID", SqlDbType.Int).Value = empobj.CompanyId;
                    cmd.Parameters.Add("@Password", SqlDbType.VarChar, 50).Value = empobj.Password;
                    cmd.Parameters.Add("@PasswordSalt", SqlDbType.VarChar, 100).Value = Guid.NewGuid().ToString();
                    cmd.Parameters.Add("@AccessToken", SqlDbType.VarChar, 100).Value = accessToken;
                    cmd.Parameters.Add("@DeviceUUID", SqlDbType.VarChar, 50).Value = empobj.DeviceUUID;
                    cmd.Parameters.Add("@DeviceType", SqlDbType.VarChar, 50).Value = empobj.DeviceType;
                    cmd.Parameters.Add("@CreatedDate", SqlDbType.VarChar, 50).Value = System.DateTime.Now;
                    cmd.Parameters.Add("@IsDeleted", SqlDbType.VarChar, 50).Value = empobj.IsDeleted;
                    cmd.Parameters.Add("@DeletedDate", SqlDbType.Date).Value = System.DateTime.Now;
                    result = Convert.ToInt32(cmd.ExecuteNonQuery());
                    switch (result)
                    {
                        case 1:
                            empResponse.Status = true;
                            empResponse.Message = "User successfully registered.";
                            empobj.AccessToken = accessToken;
                            break;
                        case 2:
                            empResponse.Status = false;
                            empResponse.Message = "Email already exists.";
                            break;
                        default:
                            empResponse.Status = false;
                            empResponse.Message = "Registration failed.";
                            break;
                    }
                }
            }
            catch (SqlException ex)
            {
                Logger.LogException(ex);
                empResponse.Status = false;
                empResponse.Message = ex.Message;
            }
            return empResponse;
        }